HPMC stands for Hydroxypropyl methylcellulose, also known as hypromellose. It is a semi-synthetic, neutral, and viscoelastic polymer.
HPMC is a water-soluble, biodegradable, and biocompatible polymer that has a wide range of applications such as drug delivery, dyeing, cosmetics, adhesives, coatings, agriculture, and textiles.
Physical and Chemical Properties:
HPMC is a solid substance and is white to cream powder in appearance and may be granular. This compound forms a colloid when dissolved in water. It is non-toxic and combustible and can react strongly with oxidizing agents. Hypromellose in an aqueous solution, such as methylcellulose, exhibits thermal gelling. This means that when the solution is heated to a critical temperature, it becomes a non-flowing but flexible mass. These properties are quite similar to the concentration of the methoxy group.
|Product Name||Hydroxypropyl methylcellulose|
|Chemical formula||It varies – it depends on the substitutions of the alkyl group|
|Molar mass||It varies – it depends on the substitutions of the alkyl group|
|Appearance||Granulation powder – solid – white|
|Solubility in water||soluble|
|Solubility||Soluble in most polar organic solvents|
Insoluble in diethyl ether, acetone, and anhydrous alcohol
|form||White to cream|
|Other names||Hydroxypropyl methylcellulose; hydroxypropyl methylcellulose; HPMC|
|Chemical Structure Depiction|
HPMC production process:
It is a semi-synthetic compound. Semi-synthetic means that the compound produced is extracted and purified from natural sources. Cultivation in laboratory environments and extraction of materials from plants leads to the production of semi-synthetic chemical compounds such as cellulose derivatives, which are used as raw materials for the preparation of other similar compounds. These compounds, like the HPMC polymer compound, are high-weight molecules and are almost complex in molecular structure.
This compound is produced by purifying fibrous plant materials with sodium hydroxide methyl chloride and propylene oxide.
R cell–OH+ NaOH+ CH3Cl +CH2OCHCH3→R cell–O–CH2OHCHCH3 + NaCl + H2O
Applications and uses of hydroxypropyl methylcellulose:
The most important applications of HPMC is as follows:
- In the tile adhesive industry: This material is used in building materials such as tile adhesive, which is used as a rheology modifier and water-retaining material.
- Pharmaceutical industry.
- Application in paint and coating industries: Used as a thickener, dispersant, and stabilizer in the coating industry, it has good solubility in water or organic solvents and is also known as a paint cleaner.
- Production of gypsum products.
- Usage in the production of cosmetics – detergents.
- Provide eye contact lenses.
- Production of eye drops.
- Production of whole-grain bread and cereals containing gluten: Use of vegetable HPMC as a substitute for gluten in the preparation of oatmeal and other bread.
- Use as a creator of geological properties and water-retaining material in building materials.
- In the plastics industry, it is used as a reducing, softening, lubricating, and etc.
- Used as a dispersing agent in PVC production.
HPMC in the eye drops:
Hypromellose solutions have been approved as a semi-synthetic alternative to artificial tears. Its molecular structure is based on a celluloid compound that is highly soluble in water. This compound lubricates the cornea, thus reducing eye irritation and preventing dry eyes.
Safety information :
Very serious allergic reactions to this drug are rare. See a doctor immediately away if you have a severe allergic reaction to this compound, including itching, redness of the skin, blistering, tightness in the chest or throat, difficulty breathing, and hoarseness.
- Skin Contact: Immediately flush skin with water.
- Inhalation: move the person to the fresh air.
- Eye Contact: Rinse eyes with water for at least 15-20 minutes.
- Ingestion: Do not induce vomiting. Get medical aid immediately. Call a poison control center.
Packing and storage:
Keep the container tightly closed in a dry and well-ventilated place. Store away from incompatible materials.